Loratadine Side Effects: What You Need to Know Before Taking It

When you reach for loratadine, a common non-drowsy antihistamine used to treat allergy symptoms like sneezing, runny nose, and itchy eyes. Also known as Claritin, it’s one of the most popular over-the-counter options for managing seasonal allergies. Unlike older antihistamines, it doesn’t usually make you sleepy — which is why millions take it daily. But even though it’s mild, it’s not risk-free. Side effects happen, and knowing what to watch for can save you from unnecessary discomfort or worse.

Most people tolerate loratadine just fine. But some report headaches, dry mouth, or mild stomach upset. Less common, but still possible, are dizziness, fatigue, or even rapid heartbeat. If you’re over 65, have liver problems, or take other meds like erythromycin or ketoconazole, your body might process it slower — increasing the chance of side effects. It’s not just about the drug itself; it’s about how your body interacts with it. People with asthma or kidney disease should also talk to their doctor first. And while loratadine doesn’t usually cause drowsiness, some folks still feel tired — especially when starting out or taking higher doses.

It’s also worth knowing how loratadine stacks up against other allergy meds. Unlike cetirizine (Zyrtec), which can cause drowsiness in some, or fexofenadine (Allegra), which has fewer interactions, loratadine sits in the middle — effective, affordable, and generally safe. But safety isn’t one-size-fits-all. If you’ve had bad reactions to antihistamines before, or if you’re pregnant or breastfeeding, you need personalized advice. The posts below cover real experiences, drug interactions, and what to do if side effects pop up — from mild to rare. You’ll find practical tips from people who’ve been there, plus clear breakdowns of when to call a doctor and when it’s just a normal adjustment period.