Heartburn Medicine: What Works, What Doesn’t, and How to Choose

When heartburn medicine, medications used to relieve the burning sensation caused by stomach acid rising into the esophagus. Also known as acid reflux treatment, it includes everything from over-the-counter antacids to prescription drugs that stop acid production at the source. Most people reach for heartburn medicine after a spicy meal or late-night snack, but not all of it is created equal. Some give quick relief, others fix the problem long-term—and some do more harm than good if used wrong.

There are three main types: antacids, fast-acting compounds that neutralize stomach acid on contact, like Tums or Rolaids, H2 blockers, drugs like famotidine that reduce acid production for several hours, and proton pump inhibitors, stronger medications like omeprazole that shut down acid production at the cellular level. Antacids work fast but don’t last. H2 blockers take a bit longer but last longer. PPIs are the most powerful, but they’re not meant for daily use without a doctor’s guidance. Too many people pop PPIs like candy, not realizing long-term use can lead to nutrient loss, bone weakness, or even infections.

What’s missing from most people’s routine? Knowing when heartburn is just discomfort and when it’s a sign of something bigger. If you’re using heartburn medicine more than twice a week, or if it stops working, that’s not normal. It could be GERD, a hiatal hernia, or even a sign of esophageal damage. And no, swallowing a pill every day isn’t a fix—it’s a bandage. The real solution often involves lifestyle changes: eating smaller meals, avoiding lying down after food, cutting out caffeine and alcohol. But if you need medicine, you should know exactly what you’re taking and why.

There’s no one-size-fits-all heartburn medicine. What helps your neighbor might do nothing for you—or make things worse. That’s why the best approach is simple: understand your options, match them to your symptoms, and don’t ignore the red flags. Below, you’ll find real, tested insights on what works, what doesn’t, and how to use these drugs safely without falling into common traps.